化學(xué)配方數(shù)據(jù)庫(kù)
| 配方類型： |
DRUGS |
| 配方說(shuō)明： |
Tablets (Griseofulvin, 250 mg) |
| 配方組成： |
"Cab-O-Sil" M-7/9.00 mg/tablet
Starch Paste (30% W/V)/10.00 mg/tablet
"Veegum" F/50.00 mg/tablet
"Emdex"/60.00 mg/tablet
"Avicel" PH 101/115.00 mg/tablet
Lactose/100.00 mg/tablet
Griseofulvin (micronized)/250.00 mg/tablet
Stearic Acid/6.00 mg/tablet |
| 配制方法： |
Prepare a wet granulation of griseofulvin. Mix the griseofulvin, lactose, and starch paste and pass through a 14-mesh sieve. Dry the granules in a 60 C oven for 6 h. Collect granules passing through a 20-mesh sieve. Combine griseofulvin granules, "Veegum" F, "Emdex," and "Avicel" PH 101 and mix for 15 min. Add the stearic acid and "Cab-O-Sil" to the mixture and blend for an additional 10 min. Compress.
Mean Tablet Wt. (n=20)---597 mg Mean hardness---7 kg Friability---0.27% Disintegration Time (Purified water)---3 min |
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